PEA and Luteolin for Smell Loss After COVID or a Virus: The Trial Evidence
Three randomized trials and a meta-analysis tested PEA plus luteolin for post-viral smell loss. All added it to olfactory training. What that means for you.
PEA for Depression and Bipolar Mania: What the Randomized Trials Show
What randomized trials of PEA in major depression and acute mania found, how the inflammation hypothesis fits, and how to read the results overall.
PEA for Restless Legs Syndrome: What a New Case Report Suggests
A case report on PEA for restless legs syndrome: what it documented, why the mechanism is plausible, and why one case is not evidence of effect.
PEA for Menstrual Pain: What a 2025 Clinical Trial on Palmitoylethanolamide Found
What a 2025 randomized trial of PEA for menstrual pain tested, how large the effect was, and what the study does not tell you about dysmenorrhea.
PEA for Dental Pain and TMJ: What the Nerve Pain and Anti-Inflammatory Research Suggests
What the human trial on PEA for TMJ pain found, what animal research adds, and how the nerve pain evidence applies to dental pain more broadly.
PEA for Sciatica: Can Palmitoylethanolamide Help With Nerve Root Pain?
What the sciatica evidence for PEA rests on: a post hoc reanalysis, newer delivery research, and how it differs from PEA’s other pain evidence.
Palmitoylethanolamide (PEA) vs NSAIDs: Evaluating a Long-Term Option for Inflammatory Pain
How does PEA compare to ibuprofen and naproxen for inflammatory pain? We examine the mechanisms, clinical evidence, and safety profiles of both.
Stacking PEA With Other Supplements: Luteolin, Omega-3, and What the Evidence Suggests
Explore how palmitoylethanolamide (PEA) may combine with luteolin, omega-3s, and other supplements—mechanisms, practical considerations, and honest caveats.
Palmitoylethanolamide and PPAR-α: The Molecular Switch Behind Its Anti-Inflammatory Action
Learn how PEA activates the PPAR-α nuclear receptor to reduce inflammation and pain—what the science shows and what it means for supplementation.
Palmitoylethanolamide and Multiple Sclerosis: What the Evidence Shows About Neuroinflammation and Neuropathic Pain
PEA is an endogenous fatty acid amide studied for neuroinflammation and pain in multiple sclerosis. Here is what current evidence shows.
Palmitoylethanolamide (PEA) for IBS and Visceral Pain: Mast Cell Stabilization in the Gut
Explore how PEA may reduce IBS gut pain through mast cell stabilization and PPAR-α activation. Evidence-based overview with cited research.
Palmitoylethanolamide Drug Interactions: What the Evidence Says Before Combining With Medications
What does the research actually say about palmitoylethanolamide drug interactions? An honest, evidence-based look at PEA and medications.