PEA for Shingles Nerve Pain (Postherpetic Neuralgia): A Genuinely Thin Evidence Base
PEA is often listed for postherpetic neuralgia. The actual evidence is one 8-patient open trial of a cream and two case reports. Here is all of it.
PEA for Vulvodynia and Vestibulodynia: What the Randomized Trial Really Found
A randomized trial added PEA and polydatin to TENS therapy for vestibulodynia. Both groups improved equally. The one subgroup where it made a difference matters.
PEA After a Stroke: What the 250-Patient Rehabilitation Study Actually Showed
250 stroke patients in rehabilitation took PEA with luteolin for 60 days and all measures improved. There was no control group, and that changes everything.
PEA Creams for Eczema and Itchy Skin, and Why Oral PEA Is a Different Question
Nearly all human evidence for PEA in eczema and itch comes from creams, not capsules. What the topical trials found, and why the oral question stays open.
PEA for Colds and Flu: What the Upper Respiratory Infection Trials Actually Show
A 426-person randomized trial and three 1970s army field trials tested PEA against respiratory infection. The numbers are real, and so are the caveats.
PEA for Chronic Prostatitis and Male Pelvic Pain (CP/CPPS)
Two studies tested PEA in chronic prostatitis and chronic pelvic pain syndrome. Both used combination products, one had no placebo and one was a suppository.
PEA and Luteolin in Frontotemporal Dementia: What the Phase 2 Trial Showed
A Phase 2 randomized placebo-controlled trial tested PEA with luteolin in 48 frontotemporal dementia patients for 24 weeks. The result, and its strict limits.
Is PEA Safe for Children? What the Pediatric IBS Trial Shows
One randomized trial gave PEA with polydatin to 70 children aged 10 to 17 for 12 weeks. What it found on symptoms and safety, and what it cannot tell parents.
PEA for Burning Mouth Syndrome: The 600 mg Trial and What Came After
A preliminary randomized double-blind trial tested ultramicronized PEA at 600 mg twice daily for burning mouth syndrome. What it found, and how it compares.
PEA and Luteolin for Smell Loss After COVID or a Virus: The Trial Evidence
Three randomized trials and a meta-analysis tested PEA plus luteolin for post-viral smell loss. All added it to olfactory training. What that means for you.
PEA for Allergic Rhinitis and Hay Fever: What the Randomized Trial Actually Found
A randomized placebo-controlled trial tested PEA for seasonal hay fever. It missed its primary endpoint. What the subgroup and blood markers showed instead.
PEA for Depression and Bipolar Mania: What the Randomized Trials Show
What randomized trials of PEA in major depression and acute mania found, how the inflammation hypothesis fits, and how to read the results overall.